TABLE 3

Fraction unbound in plasma and tissues, fraction un-ionized in blood (f_uib) and tissues (f_uit) (%) and blood-to-plasma concentration ratio (BP) in rats

Compound	f_ut														f_up	f_uib	f_uit	BP
Compound	Lung	Brain	Heart	Bone	Muscle	Adipose	Skin	Thymus	Kidney	Testes	Liver	Spleen	Pancreas	Intestine	f_up	f_uib	f_uit	BP
	%
Cefotetan	31	26	23	23	15	25	14	19	24	26	16	24	17	21	41	3.4 × 10⁻⁹	2.1 × 10⁻⁸	0.9
Cefazolin	39	73	78	26	53	39	21	26	56	51	39	73	41	22	13	1.6 × 10⁻³	4.0 × 10⁻³	0.5
Cefpiramide	33	41	33	24	20	24	11	21	32	48	23	47	36	39	31	1.6 × 10⁻³	4.2 × 10⁻³	0.5
Cefoperazone	44	54	51	41	22	33	28	33	27	40	39	42	38	33	36	1.6 × 10⁻³	4.2 × 10⁻³	1.1
Furosemide	22	20	13	22	9.5	21	14	17	10	25	10	21	18	30	1.3	0.0043	0.011	1.1
Diclofenac	11	4.2	3.1	16	4.4	10	5.4	3.8	4.4	6.7	1.9	4.9	2.3	2.1	0.78	0.060	0.15	0.6
Rosuvastatin	91	62	39	80	29	100	67	52	35	51	32	48	36	74	8.4	0.071	0.18	0.7
Fluvastatin	2.9	0.61	0.64	0.88	0.53	4.8	1.0	0.54	0.71	0.95	0.47	0.78	0.71	0.54	0.60	0.074	0.19	1.0
Warfarin	31	22	16	60	17	31	11	15	21	27	7.0	18	6.0	7.9	1.4	0.13	0.32	0.6
Ethinylestradiol	1.9	0.23	0.78	1.5	1.0	0.57	0.52	0.68	0.71	1.5	0.71	1.1	1.6	1.0	1.6	100	100	0.8
Cyclosporine	2.7	1.2	1.1	3.6	1.3	0.57	0.17	0.17	0.40	0.13	0.81	0.23	0.61	0.23	2.9	100	100	0.7
TC1	48	30	26	60	21	25	12	26	24	19	16	10	4.0	4.4	19	100	100	0.7
C2	29	24	19	61	23	23	12	34	22	26	17	16	8.7	17	10	100	100	0.7
TC3	37	22	26	70	22	36	17	38	16	15	14	13	9.3	10	27	100	100	0.6
Diazepam	8.9	5.6	4.2	11	5.5	1.0	1.3	2.7	5.5	6.4	2.8	5.7	0.88	2.8	11	100	100	0.8
TC4	0.51	0.040	0.037	0.097	0.052	0.16	0.35	0.18	0.11	0.22	0.31	0.073	0.54	0.10	0.26	100	99	0.7
TC5	1.4	1.1	0.88	3.0	1.1	0.24	0.20	0.71	1.2	0.92	0.51	0.47	0.23	0.74	1.8	100	99	0.6
Midazolam	5.6	3.3	3.4	6.9	7.1	1.8	0.71	2.1	3.9	4.9	2.2	3.8	1.0	1.3	2.8	99	96	0.9
TC6	9.5	5.6	6.5	1.2	6.1	6.6	5.2	1.1	4.3	4.8	2.1	4.2	1.0	1.4	0.30	98	95	0.6
TC7	1.6	0.81	0.81	0.13	1.4	0.70	0.36	0.27	0.81	1.3	0.47	1.2	0.61	1.0	0.10	97	92	0.4
TC8	9.5	5.6	6.5	1.2	6.1	6.6	5.2	1.1	4.3	4.8	2.1	4.2	1.0	1.4	0.70	97	92	0.5
Nicardipine	1.8	0.54	0.71	0.57	1.7	0.49	0.83	0.71	0.85	1.0	0.51	0.92	0.74	0.64	1.4	56	34	0.8
TC9	6.2	3.2	2.9	5.0	3.5	8.7	4.4	2.4	3.3	3.4	0.85	1.7	0.78	0.74	3.0	19	8.5	1.1
Erythromycin	57	51	44	42	49	39	25	54	41	47	44	57	11	8.5	48	15	6.5	1.1
Lidocaine	92	63	60	100	94	100	68	100	30	65	58	100	58	100	38	6.9	2.9	1.3
Verapamil	15	13	7.3	10	6.8	14	1.5	8.2	9.1	8.7	2.8	11	0.34	0.44	4.0	2.6	1.1	1.2
Propranolol	7.8	4.1	3.6	5.6	6.1	6.2	1.3	4.5	4.5	4.9	1.7	5.5	2.3	0.88	8.8	1.8	0.72	1.2
Metoprolol	62	46	46	45	45	46	25	39	54	33	37	45	14	10	80	1.7	0.67	1.0
Quinidine	3.2	8.9	6.3	1.3	5.0	8.4	0.60	1.5	5.3	6.3	1.3	6.0	0.20	0.80	17	1.3	0.52	1.1
Propafenone	4.8	1.9	1.5	1.9	3.4	9.0	1.6	2.7	1.9	2.5	0.78	2.7	5.4	0.47	2.2	1.3	0.51	1.1
Irinotecan	18	9.3	12	10	15	25	12	10	9.1	11	5.7	12	5.9	9.2	5.1	1.1	0.45	0.9
Imipramine	3.8	3.5	2.2	4.0	3.5	2.2	0.68	2.2	2.9	2.3	1.1	2.7	1.0	0.57	15	0.81	0.32	1.4
Citalopram	12	9.2	7.3	15	8.3	20	1.9	12	8.9	12	4.0	13	0.47	0.88	40	0.67	0.27	1.2
Disopyramide	39	38	38	35	31	28	19	35	45	42	37	49	30	25	61	0.20	0.079	1.1
Naltrexone	38	40	43	40	35	56	28	42	51	56	38	56	24	25	48	42	23	2.1
Dasatinib	2.5	1.2	0.88	1.2	1.2	3.4	1.3	0.88	1.2	1.6	0.47	0.81	0.37	0.30	2.0	87	72	1.4