Cmax | Tmax | t1/2 | CLtot | Vdss | AUCinf | |
---|---|---|---|---|---|---|
ng/ml | h | h | ml/(h · kg) | ml/kg | h · ng/ml | |
Midazolam | ||||||
+ Vehicle | 3.1 ± 0.4 | 651 ± 93 | 2865 ± 174 | 312 ± 47 | ||
+ 5 mg/kg ketoconazole | 3.2 ± 0.3 | 751 ± 39 | 3416 ± 370 | 267 ± 13 | ||
+ 10 mg/kg ketoconazole | 4.1 ± 0.6* | 629 ± 55 | 3706 ± 838 | 320 ± 26 | ||
Ketoconazole | ||||||
5 mg/kg | 231 ± 224 | 2.5 ± 1.0 | 5.9 ± 2.6 | 660 ± 418 | ||
100 mg/kg | 2891 ± 2132 | 7.0 ± 2.0 | 5.5 ± 4.2 | 32,403 ± 25,428 |
↵* p < 0.05, compared with the vehicle.