Cmax | Tmax | t1/2 | AUCinf | |
---|---|---|---|---|
ng/ml | h | h | h · ng/ml | |
Buspirone | ||||
+ Vehicle | 0.51 ± 0.42 | 1.0 ± 0.0 | 1.43 ± 0.35 | 1.18 ± 0.86 |
+ Ketoconazole | 8.52 ± 4.84* | 1.3 ± 0.5 | 1.15 ± 0.41 | 15.15 ± 4.67* |
Carbamazepine | ||||
+ Vehicle | 761 ± 214 | 1.1 ± 0.3 | 2.57 ± 0.17 | 2367 ± 1442 |
+ Ketoconazole | 663 ± 235 | 1.0 ± 0.0 | 2.49 ± 0.29 | 2351 ± 1787 |
Diazepam | ||||
+ Vehicle | 30.4 ± 14.9 | 1.3 ± 0.5 | 3.37 ± 1.49 | 90.6 ± 43.6 |
+ Ketoconazole | 39.3 ± 42.7 | 2.1 ± 2.6 | 3.32 ± 1.10 | 156 ± 149 |
Felodipine | ||||
+ Vehicle | 0.92 ± 0.38 | 3.5 ± 1.0 | 7.68 ± 3.81 | 12.2 ± 7.30 |
+ Ketoconazole | 6.09 ± 5.33 | 1.5 ± 0.6 | 5.30 ± 2.16 | 32.7 ± 20.6 |
Midazolam | ||||
+ Vehicle | 37.4 ± 16.3 | 2.0 ± 0.0 | 2.50 ± 1.65 | 221 ± 145 |
+ Ketoconazole | 255 ± 311 | 3.3 ± 3.2 | 2.96 ± 0.69 | 1332 ± 1321 |
Nicardipine | ||||
+ Vehicle | 67.3 ± 15.7 | 1.0 ± 0.0 | 6.17 ± 2.54 | 144 ± 36.4 |
+ Ketoconazole | 150 ± 52.1* | 1.8 ± 0.5 | 3.91 ± 0.71 | 443 ± 52.7* |
Nifedipine | ||||
+ Vehicle | 9.22 ± 2.50 | 2.5 ± 2.4 | 3.91 ± 3.28 | 43.2 ± 23.4 |
+ Ketoconazole | 75.6 ± 40.8* | 1.3 ± 0.5 | 2.02 ± 1.66 | 146 ± 47.8* |
Saquinavir | ||||
+ Vehicle | 2.49 ± 0.86 | 1.1 ± 0.6 | 9.40 ± 13.0 | 7.45 ± 4.91 |
+ Ketoconazole | 36.9 ± 19.5* | 0.8 ± 0.3 | 7.59 ± 1.65 | 66.7 ± 23.5* |
Verapamil | ||||
+ Vehicle | 1.88 ± 1.32 | 1.5 ± 0.6 | 3.22 ± 1.40 | 10.4 ± 11.4 |
+ Ketoconazole | 12.2 ± 11.6 | 1.5 ± 0.6 | 4.28 ± 2.48 | 55.5 ± 51.6 |
↵* p < 0.05, compared with vehicle.