Pharmacokinetic parameters of SMART-H in mouse, rat, and dog
The half-life is presented as harmonic mean ± pseudo-S.D. in rat.
| Mouse | Rat | Dog | |
|---|---|---|---|
| n | 3 | 4 | 1 |
| Dose (mg/kg) | 15 | 2.5 | 0.25 |
| Volume of distribution, Vss (l/kg) | 4.9 | 11 ± 4 | 0.4 |
| AUC (h · mg/ml) | 1.9 | 5.8 ± 1.1 | 1.6 |
| Ke (min−1) | 0.0049 | 0.00032 ± 0.000045 | 0.0004 |
| Half-life, t1/2 (min) | 140 | 2143 ± 292 | 1866 |
| Clearance (ml/min/kg) | 130 | 5.3 ± 0.9 | 2.7 |
| Hepatic blood flow (ml/min/kg) | 90 | 55 | 30 |
| Extraction rate | >1 | 0.1 | 0.1 |
AUC, area under the concentration-time curve.