TABLE 2

Comparison of mean values of AUC0–t last, t1/2, and Cmax for total radioactivity and elzasonan in human plasma after oral administration of [14C]elzasonan

Data are presented as means ± S.D. n = 6. Mean represents data from each subject. Eight and 11 data points were used to calculate t1/2 for elzasonan and total radioactivity, respectively.

Value
AUC0–t last (ng · h/ml)
    Elzasonan1117.4 ± 635
    Total radioactivity9071.6 ± 4043
Drug % of total radioactivity12.3
t1/2 (h)
    Elzasonan31.5 ± 13
    Total radioactivity88.4 ± 24
Cmax (ng/ml)
    Elzasonan60.4 ± 34
Cmax (ng-Eq/ml)
    Total radioactivity95.7 ± 18
Drug % of total radioactivity63.2