Covalent binding of [14C]elzasonan indole iminium ion (0.18 μM) to human liver microsomes under various conditions
Data are presented as means ± S.D. Means represent three replicates.
| Condition | [14C]Iminium Ion-Related Radioactivity Bound |
|---|---|
| pmol/mg microsomal protein | |
| Control | 1.9 ± 0.6 |
| +KCN (1.0 mM) | 0.8 ± 0.05 |
| +GSH (10 mM) | 0.7 ± 0 |
| +NADPH (1.3 mM) | 4.0 ± 0.2 |