Inhibitory activities of BMS-690514 and its primary metabolites in enzymatic and cell-based assays
| IC50 | ||||
|---|---|---|---|---|
| HER1 (EGFR) | HER2 | VEGFR2 | N87 (Cell Proliferation) | |
| nM | ||||
| BMS-690514 | 5 | 19 | 45 | 27 |
| M1 | >1000 | >1000 | >1000 | N.E. |
| M2 | 24 | 36 | 828 | 230 |
| M3 | 23 | 113 | 4 | 910 |
| M6 | 20 | 24 | >1000 | >10,000 |
N.E., M1 was not evaluated in the N87 tumor cell proliferation assay.