TABLE 1

Effect of LCA feeding (0.5% for 3 days) and LCA injection (0.125 mg/g for 4 days) on hepatic and intestinal transporters and regulators of bile acid biosynthesis

Male mice; n = 6 for feeding experiments and n = 5 for injections.

		LCA Feeding Compared with Chow		LCA Injection Compared with Vehicle
		Wild Type	Pxr(−/−)	Wild Type	Pxr(−/−)
Hepatic expression	Cyp7a1	0.08*	0.30*	0.20*	0.59*
	Slc10a1	0.76	0.84	0.26*	0.80
	Slco1a1	0.71	0.66	0.11*	0.67
	Slco1b2	0.61*	0.74	0.12*	0.64*
	Abcb11	0.69*	0.89	0.42*	0.77
	Abcc2	0.63*	0.91	0.41*	0.49*
	Abcc3	0.75	0.73	1.34	0.46
	Abcc4	0.95	0.79	0.96	1.43
	Abcb1a	0.80	0.80	1.20	1.08
Intestinal expression	Fgf15	6.30*	6.27*
	Fabp6	1.32	1.98*
	Ostα	0.78*	0.98
	Ostβ	0.75	0.97

↵* p < 0.05.