A summary of the classification bins for each endpoint/assay discussed in this work

BIN AssayLow Risk (Low)Moderate Risk (Moderate)High Risk (High)
HLM stabilityClint < 9.29.2<Clint<48Clint > 48
RRCK permeabilityRRCK < 2.52.5<RRCK<10RRCK > 10
MDR P-gp effluxaMDR < 2.5MDR > 2.5
  • a For MDR only two bins are provided. Bins were formed on the basis of guidance provided by domain experts in the PDM research group.