TABLE 1

A summary of the classification bins for each endpoint/assay discussed in this work

BIN Assay	Low Risk (Low)	Moderate Risk (Moderate)	High Risk (High)
HLM stability	Cl_int < 9.2	9.2<Cl_int<48	Cl_int > 48
RRCK permeability	RRCK < 2.5	2.5<RRCK<10	RRCK > 10
MDR P-gp efflux^{^a}	MDR < 2.5		MDR > 2.5

↵a For MDR only two bins are provided. Bins were formed on the basis of guidance provided by domain experts in the PDM research group.