Effects of CB126 on the activity of hepatic microsomal alkoxyresorufin O-dealkylases in C57BL/6 and DBA/2 mice
Animals were killed 7 days after the administration of CB126 (2.5 mg/kg). Data represent the mean ± S.E. for four to five mice.
| Resolfin O-Dealkylase | C57BL/6 | DBA/2 | ||
|---|---|---|---|---|
| Control | CB126 | Control | CB126 | |
| nmol resolfin formed/mg/protein/min | ||||
| 7-Ethoxy- | 0.20 ± 0.02 | 14.29 ± 0.56* | 0.18 ± 0.01 | 0.21 ± 0.01* |
| 7-Benzyloxy- | 0.12 ± 0.02 | 0.38 ± 0.01* | 0.07 ± 0.01 | 0.10 ± 0.01 |
| 7-Pentoxy- | 0.02 ± 0.002 | 0.15 ± 0.01* | 0.02 ± 0.001 | 0.03 ± 0.003* |
↵* P < 0.05, significantly different from each control.