Up-regulated genes in brain tissues of oxycodone-treated rats
MetaCore assigned gene symbols/names are indicated in parentheses (column 1) if different from Affymetrix gene symbols/names. -Fold change values are expressed as mean ± S.D.
| Gene Symbol | Gene Title | Function | Accession No. | -Fold Change | p Value |
|---|---|---|---|---|---|
| PAIHC3 (ITIH3) | Inter-alpha trypsin inhibitor, heavy chain 3 | Hyaluronan metabolism | BE106814 | 3.4 ± 0.4 | 0.042 |
| Dusp6 (MKP-3) | Dual specificity phosphatase 6 | Regulation of cell cycle progression | AI231350 | 3.3 ± 0.1 | 0.034 |
| Sgk1 | Serum/glucocorticoid regulated kinase | Protein kinase activity | NM_019232 | 2.5 ± 0.01 | 0.039 |
| Gpd1a | Glycerol-3-phosphate dehydrogenase 1 | Carbohydrate metabolism | NM_022215 | 2.5 ± 0.02 | 0.009 |
| Similar to RIKEN cDNA 2610029K21 | Nucleic acid binding | BF410646 | 2.5 ± 0.1 | 0.003 | |
| RGD1311086a,b predicted | Similar to RIKEN cDNA, 2610029K21 (predicted) | Nucleic acid binding | BI288424 | 2.4 ± 0.1 | 0.006 |
| Fkbp5a predicted | FK506 binding protein 5 (predicted) | Protein folding | BI284255 | 2.2 ± 0.1 | 0.004 |
| Abcg2 | ATP-binding cassette, subfamily G (WHITE), member 2 | Efflux transporter | AB094089 | 2.1 ± 0.1 | 0.0004 |
| Gpd1 | Glycerol-3-phosphate dehydrogenase 1 | Carbohydrate metabolism | NM_022215 | 2.1 ± 0.5 | 0.001 |
| Sult1a1 | Sulfotransferase family 1A, phenol-preferring, member 1 | Catecholamine metabolism | AF394783 | 2.1 ± 0.02 | 0.009 |
| Rpe65 | Retinal pigment epithelium 65 | Eye development, vitamin A metabolism, visual perception | NM_053562 | 2.0 ± 0.2 | 0.003 |
| Fkbp5 predicted | FK506 binding protein 5 (predicted) | Protein folding | BI284255 | 2.0 ± 0.03 | 0.003 |
| Similar to Coronin, actin binding protein 1C | Cell adhesion | AI598550 | 2.0 ± 0.1 | 0.023 | |
| Mt1a (metallothionein-1X) | Metallothionein 2610029K21 (predicted) | Metal ion homeostasis | AF411318 | 2.0 ± 0.01 | 0.028 |
| RGD1311086b predicted | Similar to RIKEN cDNA, | Nucleic acid binding | BI288424 | 1.9 ± 0.1 | 0.001 |
| Per2 | Period homolog 2 (Drosophila) 2610029K21 (predicted) | Rhythmic process regulator | NM_031678 | 1.8 ± 0.02 | 0.026 |
| RGD1311086 predicted | Similar to RIKEN cDNA, | Nucleic acid binding | BI288424 | 1.8 ± 0.1 | 0.007 |
| (CD163)b | CD163 antigen (predicted) | Scavenger receptor activity | AA956555 | 1.6 ± 0.4 | 0.002 |
| Smpdl3b predicted | Sphingomyelin phosphodiesterase acid-like 3B (predicted) | Carbohydrate metabolism | AW251315 | 1.6 ± 0.1 | 0.016 |
| Dio2 | Deiodinase, iodothyronine, type II | Thyroid hormone generation | AW526991 | 1.5 ± 0.2 | 0.049 |
| Lims2 predicted (PINCH-2) | LIM and senescent cell antigen-like domains 2 (predicted) | Zinc ion binding | BI275904 | 1.5 ± 0.3 | 0.022 |
| Klf15 (KLF15) | Kruppel-like factor 15 | Nucleic acid binding | NM_053536 | 1.5 ± 0.02 | 0.006 |
| Cryab (Alpha crystalline B) | Crystallin, alpha B | Eye development | NM_012935 | 1.5 ± 0.01 | 0.043 |
| Thrsp (S14 protein) | Thyroid hormone responsive protein | Lipid metabolism | NM_012703 | 1.5 ± 0.04 | 0.009 |
| Dsipi [DSIPI (GILZ)] | Delta sleep-inducing peptide, immunoreactor | Fluid secretion | NM_031345 | 1.5 ± 0.01 | 0.006 |
| Net1 predicted | Neuroepithelial cell transforming gene 1 (predicted) | Guanyl-nucleotide exchange factor activity | AI180187 | 1.5 ± 0.02 | 0.020 |
| (SRX1)b | Neoplastic progression 3 | DNA binding | AI172302 | 1.5 ± 0.04 | 0.011 |
| Nt5 (5′-NTD) | 5 Nucleotidase | DNA metabolism | NM_021576 | 1.5 ± 0.2 | 0.003 |
| Usp2 (UBP41) | Ubiquitin-specific protease 2 | Ubiquitin-dependent protein catabolism | AF106659 | 1.5 ± 0.01 | 0.008 |
| RGD1309044 predicted | Similar to RIKEN cDNA 0610039C21 (predicted) | Nucleic acid binding | BI278288 | 1.5 ± 0.02 | 0.036 |
| Tac2 (Nk3) | Tachykinin 2 | Neuropeptide signaling synaptic transmission | NM_019162 | 1.5 ± 0.2 | 0.041 |