Elimination rate constants of compounds from the brain
The elimination rate constant for elimination of the compounds from the brain (kel) was obtained by fitting the 100 − BEI (percent) versus time data. The data used for the calculation are shown in Fig. 4. Data represent mean ± computer-calculated S.D.
| Compound | Elimination Rate Constant (kel) | 95% Confidence Interval: Wild-Type − Oatp1a4(−/−) | |
|---|---|---|---|
| Wild-Type | Oatp1a4(−/−) | ||
| Pitavastatin | 0.015 ± 0.002 | 0.0031 ± 0.0011 | 0.0060–0.018 |
| Rosuvastatin | 0.17 ± 0.02 | 0.068 ± 0.014 | 0.056–0.14 |
| Pravastatin | 0.019 ± 0.002 | 0.0086 ± 0.0011 | 0.0060–0.014 |
| Taurocholate | 0.021 ± 0.002 | 0.0042 ± 0.0017 | 0.011–0.022 |