TABLE 3

Mechanism-based inhibition of P450s by dietary compounds in human liver microsomes^a

Inhibitor	P450	k_inact	K_{i app}	k_inact/K_{i app}
		min¹	μM
Sesamin	2C9	0.13 ± 0.01	22.0 ± 2.8	0.0059 ± 0.0004
Lignans^{^a}	3A4	0.23∼0.32	0.082∼0.37	0.84∼5.7
Bergamottin^{^b}	3A4	0.30	4.2	0.071

K_{i app} and k_inact values represent mean ± S.D. from three separate experiments.
↵a Usia et al., 2005.
↵b Zhou et al., 2004.