TABLE 2

Pharmacokinetic parameters after administration of ¹¹¹In-rHSA monomer and dimer after intravenous administration to nephrotic model rats

All nephrotic model rats received a single injection of ¹¹¹In-rHSA monomer or dimer at a dose of 1 mg/kg. At each time after the injection of ¹¹¹In-rHSA monomer or dimer, a blood sample was collected from the tail vein and plasma was obtained. Each parameter was calculated by MULTI using a two-compartment model. Each value represents the mean ± S.D. (n = 6).

	¹¹¹In-Monomer	¹¹¹In-Dimer
t_1/2 (h)	7.0 ± 1.9	13.5 ± 2.4^**
AUC (h · % of dose/ml)	56 ± 15	177 ± 15^**
CL (ml/h)	1.8 ± 0.4	0.56 ± 0.1^*
V_dss (ml)	15.3 ± 0.7	13.5 ± 0.3
Renal CL (ml/h)	1.8 ± 0.5	0.20 ± 0.12^**

↵* p < 0.05 and
↵** p < 0.01 versus ¹¹¹In-monomer.