MS response areas and %MS of levorphanol, levallorphan, and the observed metabolites after 60-min incubations with recombinant CYP2D6 and CYP3A4
| Compound | MS Response Area (107 cps) | %MSa | ||
|---|---|---|---|---|
| 3A4 | 2D6 | 3A4 | 2D6 | |
| Levorphanol (1) | 7.40 | 7.91 | 57 | 67 |
| 3 | 2.54 | 3.15 | 20 | |
| 4 | 0.40 | 3.1 | 27 | |
| 5 | 0.77 | 0.41 | 6 | |
| 6 | 0.72 | 0.41 | 5.6 | 3.4 |
| 7 | 0.16 | 1.2 | ||
| 8 | 0.39 | 0.38 | 3.1 | 3.2 |
| Levallorphan (2) | 5.59 | 7.71 | 39 | 84 |
| 6 | 1.90 | 0.299 | 13 | 3.2 |
| 9 | 2.41 | 17 | ||
| 10 | 1.29 | 0.240 | 9 | 2.6 |
| 11 | 0.819 | 0.52 | 5.7 | 5.6 |
| 12 | 0.53 | 3.7 | ||
| 13 | 0.417 | 2.9 | ||
↵a %MS calculated from MS response area divided by the summed areas of all the metabolites and parent.