Formation kinetics of 1,3-dimethyluric acid from theophylline in rat hepatocytes and hepatic microsomes
| In Vitro System | Km, 1 | Km, 2 | Vmax1 | Vmax2 | CLint1 | CLint2 |
|---|---|---|---|---|---|---|
| mM | mM | nmol/min/g liver | μl/min/g liver | |||
| Microsomes | 0.29 ± 0.08 | 10.3 ± 4.2 | 1.5 ± 0.4 | 13.9 ± 4.0 | 5.4 ± 2.8 | 1.4 ± 0.3 |
| Hepatocytes | 0.11 ± 0.04 | 5.4 ± 3.6 | 3.9 ± 1.6 | 8.0 ± 2.8 | 35.0 ± 8.7 | 2.2 ± 1.6 |