Potencya Towards P450 Isoform | Specificityb (1 − Iinh) | ||||||
---|---|---|---|---|---|---|---|
2C8 | 3A4 | 2D6 | 2C9 | 1A2 | 2C19 | ||
Albendazole | 0.19 | 0.00 | 0.12 | 0.07 | 0.30 | 0.10 | 0.17 |
Amiodarone | 0.00 | 0.00 | 0.09 | 0.00 | 0.00 | 0.00 | 0.91 |
Amitriptyline | 0.19 | 0.12 | 0.84 | 0.00 | 0.07 | 0.64 | 0.29 |
Artemisinin | 0.11 | 0.25 | 0.04 | 0.00 | 2.08 | 0.18 | 0.56 |
Astemizole | 0.28 | 0.97 | 0.86 | 0.00 | 0.00 | 0.19 | 0.33 |
Atenolol | 0.12 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 |
Bepridil | 0.02 | 0.17 | 3.00 | 0.00 | 0.00 | 0.11 | 0.78 |
Budesonide | 0.52 | 1.35 | 0.21 | 0.73 | 0.07 | 0.12 | 0.22 |
Carbamazepine | 0.06 | 0.11 | 0.00 | 0.08 | 0.04 | 0.19 | 0.18 |
Chloroquine | 0.19 | 0.00 | 0.10 | 0.05 | 0.10 | 0.09 | 0.15 |
Chlorpheniramine | 0.07 | 0.00 | 0.68 | 0.00 | 0.28 | 0.00 | 0.55 |
Chlorthalidone | 0.06 | 0.00 | 0.00 | 0.03 | 0.02 | 0.18 | 0.41 |
Cimetidine | 0.47 | 0.06 | 0.29 | 0.11 | 0.22 | 1.05 | 0.21 |
Cisapride | 0.10 | 0.12 | 0.28 | 0.10 | 0.15 | 0.11 | 0.05 |
Clotrimazole | 2.10 | 3.00 | 1.13 | 2.85 | 1.90 | 2.06 | 0.02 |
Clozapine | 0.18 | 0.06 | 0.21 | 0.19 | 0.27 | 0.24 | 0.04 |
Cyclosporin | 0.00 | 1.61 | 0.11 | 0.00 | 0.00 | 0.10 | 0.76 |
Danazol | 1.76 | 0.18 | 1.66 | 1.95 | 0.28 | 1.70 | 0.12 |
Dexamethasone | 0.12 | 0.02 | 0.00 | 0.07 | 0.00 | 0.00 | 0.47 |
Digoxin | 0.10 | 0.06 | 0.00 | 0.09 | 0.05 | 0.09 | 0.12 |
Diltiazem | 0.08 | 0.00 | 0.04 | 0.00 | 0.06 | 0.04 | 0.24 |
Diphenhydramine | 0.09 | 0.04 | 0.68 | 0.03 | 0.00 | 0.06 | 0.52 |
Diphenylhydantoin | 0.09 | 0.00 | 0.00 | 0.29 | 0.00 | 0.08 | 0.49 |
Disulfiram | 2.33 | 1.59 | 0.46 | 2.03 | 1.92 | 1.35 | 0.05 |
Erythromycin | 0.00 | 0.22 | 0.00 | 0.06 | 0.00 | 0.07 | 0.49 |
Felbamate | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 |
Fluconazole | 0.31 | 0.97 | 0.28 | 0.74 | 0.24 | 1.23 | 0.10 |
Flurbiprofen | 0.11 | 0.00 | 0.00 | 0.92 | 0.00 | 0.05 | 0.72 |
Fluvoxamine | 0.22 | 0.11 | 0.85 | 1.03 | 3.00 | 2.42 | 0.21 |
Haloperidol | 0.12 | 0.10 | 1.54 | 0.00 | 0.21 | 0.29 | 0.42 |
Indomethacin | 0.00 | 0.00 | 0.00 | 0.60 | 0.11 | 0.14 | 0.55 |
Isradipine | 1.30 | 1.09 | 0.16 | 1.44 | 0.55 | 1.32 | 0.08 |
Ivermectin | 0.22 | 0.14 | 0.11 | 0.17 | 0.02 | 0.12 | 0.07 |
Ketoconazole | 1.42 | 3.00 | 0.91 | 1.09 | 0.63 | 1.06 | 0.08 |
Ketoprofen | 0.12 | 0.10 | 0.03 | 0.19 | 0.11 | 0.15 | 0.06 |
Lansoprazole | 1.24 | 0.26 | 0.87 | 0.72 | 1.19 | 1.54 | 0.06 |
Loratadine | 1.53 | 0.21 | 1.55 | 0.22 | 0.00 | 3.00 | 0.29 |
Lovastatin | 0.82 | 1.47 | 0.17 | 0.12 | 0.00 | 0.10 | 0.37 |
Mefloquine | 0.11 | 0.19 | 0.83 | 0.11 | 0.12 | 0.13 | 0.23 |
Methoxypsoralen | 0.18 | 0.14 | 0.80 | 0.15 | 3.00 | 0.53 | 0.34 |
Naproxen | 0.10 | 0.00 | 0.00 | 0.02 | 0.09 | 0.00 | 0.44 |
Nicardipine | 1.81 | 2.17 | 1.48 | 2.42 | 0.12 | 1.80 | 0.08 |
Nifedipine | 0.99 | 0.00 | 0.09 | 0.17 | 3.00 | 0.17 | 0.48 |
Norfloxacin | 1.56 | 3.00 | 1.29 | 1.33 | 0.92 | 1.36 | 0.04 |
Omeprazole | 0.89 | 0.22 | 0.06 | 0.17 | 0.79 | 0.29 | 0.17 |
Orphenadrine | 0.22 | 0.09 | 0.62 | 0.00 | 0.02 | 0.07 | 0.38 |
Paclitaxel | 0.10 | 0.15 | 0.06 | 0.13 | 0.13 | 0.13 | 0.02 |
Paroxetine | 0.27 | 0.68 | 2.04 | 0.24 | 1.09 | 0.93 | 0.13 |
Perphenazine | 0.26 | 0.26 | 2.68 | 0.24 | 2.13 | 0.63 | 0.25 |
Pimozide | 0.17 | 0.14 | 0.18 | 0.11 | 0.17 | 0.10 | 0.01 |
Pravastatin | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.54 |
Promethazine | 0.11 | 0.12 | 1.31 | 0.04 | 1.86 | 0.23 | 0.36 |
Propranolol | 0.00 | 0.74 | 1.26 | 0.05 | 1.05 | 1.05 | 0.21 |
Quercetin | 1.86 | 0.26 | 0.98 | 0.99 | 1.81 | 0.73 | 0.08 |
Quinapril | 0.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.91 |
Quinidine | 0.30 | 0.14 | 3.00 | 0.13 | 0.06 | 0.74 | 0.43 |
Ranolazine | 0.00 | 0.22 | 0.00 | 0.00 | 0.00 | 0.00 | 0.96 |
Sertraline | 0.26 | 0.70 | 1.48 | 0.24 | 0.85 | 1.21 | 0.10 |
Simvastatin | 1.43 | 1.68 | 0.14 | 0.17 | 0.09 | 0.11 | 0.34 |
Tamoxifen | 0.84 | 0.25 | 0.15 | 0.19 | 0.14 | 0.86 | 0.16 |
Terfenadine | 0.28 | 1.19 | 1.19 | 0.18 | 0.12 | 0.19 | 0.21 |
Ticlopidine | 0.22 | 0.00 | 0.73 | 0.17 | 0.76 | 1.60 | 0.25 |
Verapamil | 0.17 | 0.83 | 0.15 | 0.15 | 0.06 | 0.10 | 0.25 |
Warfarin | 0.15 | 0.00 | 0.02 | 1.08 | 0.03 | 0.04 | 0.64 |
↵a Potency is defined as (−log(IC50/100 μM)), so that a potency of 1 implies an IC50 of 10 μM and a potency of 2 implies an IC50 of 1 μM.
↵b Specificity is defined in terms of the entropy-based Iinh metric (eq. 2), so that a value of 0 implies a completely promiscuous inhibitor and a value of 1 implies complete specificity of inhibition.