Kinetics of bisphenol A glucuronidation by intestinal and hepatic microsomes
| Species | Gender | Microsome Matrix | Vmax | Km | CLuinta | CLh |
|---|---|---|---|---|---|---|
| pmol min−1 mg protein−1 | μM | μl min−1 mg protein−1 | ml min−1 g liver−1 | |||
| Liver | ||||||
| Rat | Male | Native | 7552 ± 553 | 4.3 ± 1.2 | 1888 | 2.0 |
| Alamethicin | 22,169 ± 1025 | 6.4 ± 1.0 | 3695 | 2.1 | ||
| Female | Native | 20,392 ± 1425 | 16.2 ± 2.9 | 1342 | 2.0 | |
| Alamethicin | 28,607 ± 2258 | 21.9 ± 4.1 | 1389 | 2.0 | ||
| Human | Male | Native | 2077 ± 186 | 3.6 ± 1.2 | 649 | 0.9 |
| Alamethicin | 9409 ± 605 | 5.6 ± 1.3 | 1882 | 0.9 | ||
| Female | Native | 4255 ± 375 | 4.9 ± 1.5 | 967 | 0.9 | |
| Alamethicin | 9389 ± 1195 | 7.3 ± 3.2 | 1444 | 0.9 | ||
| Intestine | ||||||
| Rat | Male | Native | 6599 ± 306 | 10.7 ± 1.5 | 815 | —b |
| Alamethicin | 18,795 ± 1830 | 37.0 ± 7.7 | 666 | — | ||
| Human | Mixed | Native | 487 ± 119 | 80.1 ± 35.9 | 10 | — |
| Alamethicin | 660 ± 88 | 41.9 ± 12.6 | 26 | — |