| | μM |
7-Methoxyresorufin O-demethylation (CYP1A2) | Celsis F008085-CST | 0.283 | 0.5 | 24.4 ± 1.1 |
Coumarin 7-hydroxylation (CYP2A6) | Celsis X008064-LSL | 0.202 | 2.5 | 33.5 ± 2.3 |
7-EFCa O-deethylation (CYP2B6) | Celsis M008085-JTA | 0.279 | 6.25 | 31.9 ± 2.5 |
Diclofenac 4-hydroxylation (CYP2C9) | Human Biologics Inc. 112 | 0.235 | 50 | 9.3 ± 0.2 |
S-Mephenytoin 4-hydroxylation (CYP2C19) | Puracyp 011 | 0.138 | 50 | 6.4 ± 0.1 |
7-MAMCb O-demethylation (CYP2D6) | Celsis M008085-JTA | 0.279 | 25 | 21.2 ± 1.3 |
Chlorzoxazone 6-hydroxylation (CYP2E1) | Human Biologics Inc. 227 | 0.190 | 100 | 16.0 ± 1.4 |
Testosterone 6β-hydroxylation (CYP3A4) | Human Biologics Inc. 501 | Not supplied | 50 | 8.0 ± 0.3 |
7-Benzyloxyquinoline O-debenzylation (CYP3A4) | Human Biologics Inc. 501 | Not supplied | 80 | 8.8 ± 0.5 |