Vmax [nmol/(min · nmol P450)] | 0.0473 ± 0.0069†† | 0.0697 ± 0.0115*** | 0.0232 ± 0.0041 | 0.307 ± 0.087 | 0.334 ± 0.034* | 0.203 ± 0.060 | 1.03 ± 0.23 | 1.27 ± 0.06 | 1.23 ± 0.07 |
Km (μM) | 3.27 ± 0.50 | 3.78 ± 1.15* | 2.30 ± 0.44 | 127 ± 48 | 161 ± 34 | 167 ± 31 | 6.04 ± 2.06 | 7.02 ± 2.48 | 8.36 ± 1.41 |
Vmax/Km [μl/(min · nmol P450)] | 14.5 ± 01.8 | 19.2 ± 4.3* | 10.2 ± 1.6 | 2.49 ± 0.0031 | 2.18 ± 0.63* | 1.22 ± 0.31 | 179 ± 37 | 196 ± 59 | 150 ± 20 |
Vmax/Km [μl/(min · mg microsome)] | 8.02 ± 1.07†† | 5.82 ± 0.76* | 4.29 ± 0.35 | 1.55 ± 0.35††† | 0.786 ± 0.042* | 0.444 ± 0.076 | 103 ± 40 | 71.3 ± 20.5 | 47.7 ± 23.6 |