TABLE 1

Comparison of the K_m values of rhP450 isoforms with literature values

	1A2	2C8	2C9	2C19	2D6	3A4
Specific reactions	Phenacetin O-deethylation	Paclitaxel 6-hydroxylation	Diclofenac 4′-hydroxylation	S-Mephenytoin 4′-hydroxylation	(±)-Bufuralol 1′-hydroxylation	Nifedipine oxidation
Apparent K_m (μM)^{^a}	17.5 ± 2.2	5.6 ± 0.8	5.5 ± 0.4	33.3 ± 8.2	16.1 ± 4.8	6.6 ± 1.0
Literature K_m (μM)^{^b}	1.7–152	5.4–19	3.4–52	13–35	9–15	5.1–47

↵a Values are means ± S.E. calculated from three independent experiments.
↵b Data from FDA Guidance for Drug Interaction Studies (www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm072101.pdf).