1A2 | 2C8 | 2C9 | 2C19 | 2D6 | 3A4 | |
---|---|---|---|---|---|---|
Specific reactions | Phenacetin O-deethylation | Paclitaxel 6-hydroxylation | Diclofenac 4′-hydroxylation | S-Mephenytoin 4′-hydroxylation | (±)-Bufuralol 1′-hydroxylation | Nifedipine oxidation |
Apparent Km (μM)a | 17.5 ± 2.2 | 5.6 ± 0.8 | 5.5 ± 0.4 | 33.3 ± 8.2 | 16.1 ± 4.8 | 6.6 ± 1.0 |
Literature Km (μM)b | 1.7–152 | 5.4–19 | 3.4–52 | 13–35 | 9–15 | 5.1–47 |
↵a Values are means ± S.E. calculated from three independent experiments.
↵b Data from FDA Guidance for Drug Interaction Studies (www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm072101.pdf).