Characteristics of mouse, rat, dog, monkey, and human liver microsomes used in this study
| Species | Sex | Number of Subjects Pooled | P450 Content |
|---|---|---|---|
| nmol/mg protein | |||
| Mouse | Male | 20 | 0.40 |
| Female | 18 | 0.54 | |
| Rat | Male | 23 | 0.79 |
| Female | 50 | 0.55 | |
| Dog | Male | 5 | 0.57 |
| Female | 4 | 0.43 | |
| Monkey | Male | 10 | 1.17 |
| Female | 9 | 1.31 | |
| Human | Male and female mixed | 10 | 0.36 |