Haloperidol | |||||||
---|---|---|---|---|---|---|---|
Metabolite | m/z | tR (min) | RLM | HLM | Rat Heps | Dog Heps | Human Heps |
Relative proportions of metabolites after incubation of haloperidol for 60/120 min (%) | |||||||
N-Dealk | 212 | 1.06 | 7 | 9 | 32 | 37 | 5 |
+OH+Gluc | 568 | 1.43 | N.D. | N.D. | 2 | 0 | 0 |
Gluc | 552 | 1.62 | N.D. | N.D. | 10 | 0 | 17 |
OH1 | 392 | 1.71 | 3 | 2 | 1 | 0 | 0 |
OH2 | 392 | 1.78 | 3 | 1 | 1 | 0 | 0 |
Red | 378 | 1.84 | 9 | 2 | 12 | 40 | 46 |
N-Oxide1 | 392 | 2.08 | 1 | 1 | 1 | 0 | 1 |
Pyridinium | 354 | 2.18 | 73 | 83 | 39 | 14 | 31 |
N-Oxide2 | 392 | 2.23 | 4 | 1 | 4 | 9 | 0 |
Fraction of parent drug remaining after incubation (%) | |||||||
Haloperidol | 376 | 1.97 | 55 | 59 | 77 | 81 | 86 |
Heps, hepatocytes; N.D., not determined (no addition of UDPGA in this experiment).