TABLE 3

Effect of anti-P450 antibodies on the 2-oxo-clopidogrel formation from clopidogrel and active metabolite formation from 2-oxo-clopidogrel

The assays were performed by using human liver microsomes. Anti-CYP1A2, anti-CYP2B6, anti-CYP2C19, and anti-CYP3A4 were monoclonal antibodies, and anti-CYP2C9 was polyclonal antibody. The inhibition ratio values were calculated using eqs. 4 and 5 under Materials and Methods. Data were expressed as mean ± S.D. of three experiments.