TABLE 1

Pharmacokinetic parameters of statins in rats

DoseCLtot,BBiliary ExcretionUrinary ExcretionFH
μmol/kgml/min/kg% of dose% of dose
Pravastatina0.56243<40.014
Pitavastatin12857<0.10.44–0.65b
Atorvastatin13550<0.10.29–0.56b
Fluvastatin0.5429<0.10.17–0.48b

  • ↵a Watanabe et al., 2009.

  • ↵b Estimated from eq. 3 using QH (50–80 ml/min/kg).