TABLE 2

R_B and unbound fraction in the perfusion buffer, rat plasma, and human serum, as well as f_B for each statin

	Unbound Fraction					R_B		f_B
	Perfusion Buffer	Rat Microsome	Human Microsome	Rat Plasma	Human Serum	Rat	Human^a	Rat	Human
Pravastatin	0.683	N.D.	N.D.	0.676	0.554	0.59^b	0.56	1.2	0.99
Pitavastatin	0.0489	0.418	0.432	0.0134	0.00523	0.65	0.58	0.021	0.0090
Atorvastatin	0.0817	0.557	0.405	0.0567	0.0511	1.2	0.61	0.047	0.084
Fluvastatin	0.0311	0.234	0.308	0.00986	0.00368	0.53	0.52	0.019	0.0071

N.D., not determined.
↵a Tse et al. (1993); Lennernäs and Fager (1997); FDA-approved package.
↵b Yamazaki et al., 1996b.