Parameters | Values | References |
---|---|---|
PK parameters | ||
VC (ml) | 200 | (Yamano et al., 2000) |
VPER (ml) | 400 | |
CLR (l/h) | 0.05 | |
CLint (l/h) | 0.54 | |
fu | 0.15 | (Lam et al., 2006) |
Physiological parameters | ||
QH (ml/min) | 22* | |
VH (ml) | 10* | |
kdeg (h−1) | 0.0348 | Current study |
Enzyme inhibition parameters | ||
Ki (μM) | 117 | |
kinact (min−1) | 0.04 | |
KI (μM) | 15.1 |
↵* QH and VH were calculated for individual rat as described in the text under The MDZ PK Model. The mean values were used for the simulation.