Relationship between AFE (range) and PSA, number of hydrogen bond donors, and acceptors for the proprietary compounds examined
| Property | AFE (RLM) | AFE (Hepatocytes) |
|---|---|---|
| PSA | ||
| <100 | 2.4 (0.3–12.9) | 2.9 (0.4–14.1) |
| ≥100 | 25.5 (3.7–541.1) | 19.9 (4.8–76.8) |
| Number of hydrogen bond donors | ||
| 0 | 2.5 (0.3–12.9) | 3.0 (0.4–14.3) |
| 1–2 | 18.2 (0.8–541.1) | 15.0 (0.8–76.8) |
| Number of hydrogen bond acceptors and donors | ||
| ≤7 | 2.0 (0.3–5.9) | 2.7 (0.4–7.6) |
| >7 | 16.4 (0.8–541.1) | 13.5 (0.8–76.8) |