TABLE 3

Observed and predicted -fold change in oral or intravenous midazolam AUC after indicated course of clarithromycin

Clarithromycin DoseMidazolam DoseObserved -Fold Change in AUCPredicted -Fold Change in AUC
250 mg p.o. b.i.d. for 5 days15 mg p.o.3.6a3.0
500 mg p.o. b.i.d. for 7 days4 mg p.o.7b5.3
8.6c
500 mg p.o. b.i.d. for 7 days0.05 mg/kg i.v. over 30 min2.7b2.6
2.1c

  • ↵a From Yeates et al., 1996.

  • ↵b From Gorski et al., 1998.

  • ↵c From Wang et al., 2004.