Clarithromycin Dose | Midazolam Dose | Observed -Fold Change in AUC | Predicted -Fold Change in AUC |
---|---|---|---|
250 mg p.o. b.i.d. for 5 days | 15 mg p.o. | 3.6a | 3.0 |
500 mg p.o. b.i.d. for 7 days | 4 mg p.o. | 7b | 5.3 |
8.6c | |||
500 mg p.o. b.i.d. for 7 days | 0.05 mg/kg i.v. over 30 min | 2.7b | 2.6 |
2.1c |