Parameter as Variable | Predicted AUCs, day15/AUCs, day1 | |||||
---|---|---|---|---|---|---|
Final Model: TDI Intestine and Liver, Direct Intestine Inhibition | Sensitivity Analysis (Contribution of Each Dimension of the Inhibition) | |||||
TDI Liver | Direct Intestine Inhibition | TDI Intestine | TDI Intestine, Direct Intestine Inhibition | TDI Intestine and Liver | ||
Fa, i | ||||||
0.1 | 1.43 | 1.08 | 1.06 | 1.28 | 1.32 | 1.39 |
0.2 | 1.63 | 1.14 | 1.10 | 1.37 | 1.43 | 1.56 |
0.5 | 2.08 | 1.36 | 1.20 | 1.45 | 1.53 | 1.98 |
1a | 2.81 | 1.78 | 1.31 | 1.49 | 1.58 | 2.33 |
Fg, i | ||||||
0.1 | 1.70 | 1.08 | 1.31 | 1.49 | 1.58 | 1.61 |
0.2 | 1.80 | 1.14 | 1.31 | 1.49 | 1.58 | 1.70 |
0.5 | 2.15 | 1.36 | 1.31 | 1.49 | 1.58 | 2.03 |
1a | 2.81 | 1.78 | 1.31 | 1.49 | 1.58 | 2.33 |
fu, mic, i, 0.3 mg/ml | ||||||
0.1 (0.4) | 8.54 | 5.31 | 1.42 | 1.53 | 1.61 | 8.15 |
0.2 (0.6) | 5.20 | 3.26 | 1.36 | 1.52 | 1.60 | 4.96 |
0.528a (0.87) | 2.81 | 1.78 | 1.31 | 1.49 | 1.58 | 2.33 |
1 (1) | 2.16 | 1.39 | 1.28 | 1.46 | 1.55 | 2.02 |
fp, i | ||||||
0.005 | 2.18 | 1.38 | 1.31 | 1.49 | 1.58 | 2.07 |
0.01a | 2.81 | 1.78 | 1.31 | 1.49 | 1.58 | 2.33 |
0.02 | 4.13 | 2.62 | 1.31 | 1.49 | 1.58 | 3.91 |
0.05 | 7.66 | 4.86 | 1.31 | 1.49 | 1.58 | 7.25 |
↵a Default values.