TABLE 7

Prediction of -fold increase in AUC (AUC_{s, day15}/AUC_{s, day1}) for plasma midazolam concentrations after repeated oral administration of FK1706 (60 mg) using a conventional static method by Wang et al. (2004)

Observed AUC_{s, day15}/AUC_{s, day1} was 2.

[I]_max	k_{deg, g}	k_{deg, h}	Predicted AUC_{s, day15}/AUC_{s, day1}
			Final Model: TDI in Intestine and Liver	Sensitivity Analysis (Contribution of Each Dimension of the Inhibition)
			Final Model: TDI in Intestine and Liver	TDI Liver	TDI Intestine
	h⁻¹	h⁻¹
C_{p, sys, i, max} (53.3 ng/ml)	0.0578	0.0693	23.5	14.5	1.62
	0.0210	0.00495	309	190	1.62
f_{p, i} · C_{p, sys, i, max} (0.533 ng/ml)	0.0578	0.0693	1.84	1.14	1.62
	0.0210	0.00495	4.69	2.89	1.62
C_{p, inlet, i, max} (1850 ng/ml)	0.0578	0.0693	760	470	1.62
	0.0210	0.00495	10,700	6563	1.62
C_{u, inlet, i, max} (18.5 ng/ml)	0.0578	0.0693	9.20	5.69	1.62
	0.0210	0.00495	108	66.6	1.62