Experimental conditions of cynomolgus monkey pharmacokinetic studies
The intravenous and oral administrations conditions for MDZ were taken from Sakuda et al., 2006.
| Compounds | Dosing Route | Dose | Vehicle | Volume | Sample Points |
|---|---|---|---|---|---|
| mg/kg | ml/kg | h | |||
| Lithium | Intravenous | 5 | Equivalent amount of hydrochloric acid | 1 | 0.083, 0.25, 1, 3, 5, 8, 24 |
| Oral | 10 | 2 | 0.25, 0.5, 1, 2, 4, 8, 24 | ||
| Hydrochlorothiazide | Intravenous | 1 | 50%PEG | 1 | 0.25, 1, 1.5, 4, 6, 8, 24 |
| Oral | 1 | 2 | 0.5, 1.5, 2.5, 4, 6, 8, 24 | ||
| Dexamethasone | Intravenous | 0.25 | 50%PEG | 1 | 0.083, 0.25, 1, 2, 4, 6, 8 |
| Oral | 0.5 | 2 | 0.25, 0.5, 1, 2, 4, 6, 8 | ||
| Nifedipine | Intravenous | 0.1 | 50%PEG | 1 | 0.083, 0.25, 0.5, 1, 2, 4, 5 |
| Oral | 1 | 2 | 0.25, 0.5, 1, 2, 4, 5 | ||
| Midazolam (Sakuda et. al., 2006) | Intravenous | 1 | Distilled watera | 1 | 0.1, 0.25, 0.5, 1, 2, 4, 8, 12, 24 |
| Oral | 3 | 2 | 0.25, 0.5, 1, 2, 4, 8, 12, 24 | ||
| Quinidine | Intravenous | 1 | Saline | 1 | 0.1, 0.25, 0.5, 1, 2, 4, 8, 24 |
| Oral | 3 | Distilled water | 2 | 0.25, 0.5, 1, 2, 4, 8, 24 | |
| Tacrolimus | Intravenous | 0.004 | Salineb | 0.5 | 0.083, 0.25, 0.5, 1, 4, 8, 24 |
| Oral | 0.02 | 2 | 0.25, 0.5, 1, 2, 4, 8, 24 | ||
| Verapamil | Intravenous | 1 | Saline | 1 | 0.1, 0.25, 0.5, 1, 2, 4, 8, 12, 24 |
| Oral | 3 | 2 | 0.25, 0.5, 1, 2, 4, 8, 12, 24 | ||
| Digoxin | Intravenous | 0.1 | 50%PEG | 1 | 0.1, 0.25, 0.5, 1, 2, 4, 8, 24 |
| Oral | 0.1 | 2 | 0.25, 0.5, 1, 2, 4, 8, 24 | ||
| Propranolol | Intravenous | 0.3 | Saline | 2 | 0.1, 0.25, 0.5, 1, 2, 4, 8, 24 |
| Oral | 1 | Distilled water | 2 | 0.25, 0.5, 1, 2, 4, 8, 24 | |
| Amitriptyline | Intravenous | 0.3 | Saline | 2 | 0.1, 0.25, 0.5, 1, 2, 4, 8, 24 |
| Oral | 1 | Distilled water | 2 | 0.25, 0.5, 1, 2, 4, 8, 24 | |
| Timolol | Intravenous | 0.3 | Saline | 2 | 0.1, 0.25, 0.5, 1, 2, 4, 8, 24 |
| Oral | 1 | Distilled water | 2 | 0.25, 0.5, 1, 2, 4, 8, 24 | |
| Ibuprofen | Intravenous | 1 | Saline | 2 | 0.1, 0.25, 0.5, 1, 2, 4, 8, 24 |
| Oral | 3 | 50%PEG | 2 | 0.25, 0.5, 1, 2, 4, 8, 24 |