Drugs | Species | Dose (i.v./p.o.) | CLt | fe | CLh | F | FaFg | Fh |
---|---|---|---|---|---|---|---|---|
mg/kg | ml/min/kg | % | ml/min/kg | % | ||||
Lithium | Human | (−/0.25) | 0.4 ± 0.2 | No data | 0a | 94.5 ± 15.8 | 0.95 | 1a |
Monkey | 0.14/0.27 | 0.7 ± 0.1 | No data | 0a | 97.9 ± 6.8 | 0.98 | 1a | |
Hydrochlorothiazide | Human | (−/0.32) | 3.0 ± 1.0 | 60.2 | 0a | 60.2 | 0.60 | 1a |
Monkey | 1/1 | 5.9 ± 2.0 | No data | 0a | 30.7 ± 9.4 | 0.31 | 1a | |
Dexamethasone | Human | 0.17/0.17 | 2.7 ± 0.8 | 10.8 ± 4.3 | 2.4 | 81.4 ± 15.8 | 0.93 | 0.88 |
Monkey | 0.25/0.5 | 4.5 ± 0.8 | No data | 4.5 | 78.9 ± 9.8 | 0.85 | 0.93 | |
Nifedipine | Human | 0.02/0.27 | 8.2 ± 0.6 | No data | 8.2 | 41.2 ± 5.4 | 0.89 | 0.46 |
Monkey | 0.1/1 | 15.6 ± 3.5 | 0.057 | 15.6 | 9.3 ± 4.0 | 0.19 | 0.48 | |
Midazolam | Human | 0.013/0.026 | 4.7 ± 1.5 | 0.27 ± 0.07 | 4.7 | 30.0 ± 10.0 | 0.45 | 0.67 |
Monkey | 1/3 | 12.9 ± 1.8 | <1% | 12.9 | 2.0 ± 0.4 | 0.03 | 0.62 | |
Quinidine | Human | 4.3/5.0 | 3.8 ± 0.3 | 35.1 ± 1.8 | 2.5 | 79.5 ± 15.0 | 0.96 | 0.83 |
Monkey | 1/3 | 12.8 ± 0.7 | 0.6 ± 0.2 | 12.7 | 4.5 ± 1.7 | 0.07 | 0.62 | |
Tacrolimus | Human | 0.02/0.05 | 0.5 ± 0.1 | 0.04 ± 0.02 | 0.5 | 23.3 ± 16.7 | 0.24 | 0.98 |
Monkey | 0.004/0.02 | 2.6 ± 0.3 | No data | 2.6 | 0.5 ± 0.5 | 0.005 | 0.94 | |
Verapamil | Human | 0.14/1.14 | 11.8 ± 0.5 | No data | 11.8 | 18.0 ± 10.1 | 0.47 | 0.38 |
Monkey | 1/3 | 44.9 ± 10.5 | 1.5 ± 0.7 | 44.2 | 0 | −b | 0.00 | |
Digoxin | Human | 0.01/0.01 | 2.9 ± 0.6 | 80.5 ± 3.2 | 0.6 | 65.3 ± 22.5 | 0.67 | 0.97 |
Monkey | 0.1/0.1 | 2.9 ± 0.03 | 17.1 ± 9.3 | 2.4 | 45.0 ± 14.0 | 0.48 | 0.94 | |
Propranolol | Human | 0.13/0.5 | 11.6c | No data | 11.6 | 29 | 0.78 | 0.37 |
Monkey | 0.3/1 | 24.3 ± 2.4 | No data | 24.3 | 3.3 ± 1.5 | 0.10 | 0.34 | |
Amitriptyline | Human | 0.6/1.2 | 12.5 ± 2.3 | No data | 12.5 | 47.7 ± 11.0 | 1d | 0.30 |
Monkey | 0.3/1 | 35.8 ± 8.8 | 0.2 ± 0.2 | 35.7 | 1.3 ± 1.0 | 0.03 | 0.41 | |
Timolol | Human | 0.025/0.4 | 7.7 ± 3.7 | No data | 7.7 | 61.0 ± 19.2 | 1d | 0.56 |
Monkey | 0.3/1 | 13.6 ± 0.4 | 4.8 ± 2.6 | 13 | 10.8 ± 4.3 | 0.15 | 0.71 | |
Ibuprofen | Human | 2.9/4.2 | 0.8 ± 0.2 | No data | 0.8 | 102.8 ± 12.0 | 1d | 0.93 |
Monkey | 1/3 | 7.9 ± 0.7 | 18.5 ± 1.1 | 6.4 | 103.4 ± 14.2 | 1d | 0.76 |