Median percent active hepatic CYP2D6 and CYP3A4 for EMs of CYP2D6 at steady state with different daily doses estimated with Simcyp
Data are median and range (5th and 95th percentile); n = 100.
| P450 Isoform | Active %Hepatic P450 Isoform at SS Median | ||||
|---|---|---|---|---|---|
| 10 mg/day | 20 mg/day | 30 mg/day | 40 mg/day | 50 mg/day | |
| CYP2D6 | 48 (4–85) | 8 (1–68) | 2 (0.4–50) | 1 (0.3–29) | 0.8 (0.2–10) |
| CYP3A4 | 99 (93–100) | 95 (71–100) | 82 (50–99) | 70 (39–98) | 60 (28–95) |