Tissue-specific expression of UGTs 1A6, 1A7, 1A8, 1A9, and 1A10
The data are given as mRNA copies/109 copies of 18S rRNA, mean ± S.E.
| Tissue | UGT mRNA Expression in Human Tissues | ||||
|---|---|---|---|---|---|
| 1A6 | 1A7 | 1A8 | 1A9 | 1A10 | |
| copies/109 copies of 18S rRNA, mean ± S.E. | |||||
| Adipose | 28 ± 8 | 18 ± 6 | 8 ± 2 | 86 ± 15 | 313 ± 57 |
| Adrenal gland (n = 62) | 3.0 ± 0.3 | 43 ± 9 | — | 3.0 ± 0.4 | — |
| Brain | — | — | — | — | — |
| Brain, cerebellum (n = 24) | — | — | — | — | — |
| Colon (n = 3) | 215 ± 22 | 79 ± 22 | 25 ± 8 | 188 ± 55 | 1210 ± 299 |
| Kidney | 226 ± 19 | 104 ± 12 | — | 2157 ± 269 | — |
| Liver, adult (n = 47) | 923 ± 9 | 40 ± 11 | — | 3239 ± 42 | 6.0 ± 0.2 |
| Lung | 2 ± 1 | — | — | — | — |
| Ovary | — | — | — | — | — |
| Pancreas | — | — | — | — | — |
| Placenta | 4.0 ± 0.3 | 3.0 ± 0.1 | — | 3.0 ± 0.2 | — |
| Prostate (n = 47) | 68 ± 2 | 9 ± 1 | 1 ± 1 | 8 ± 1 | 6 ± 1 |
| Small intestine (n = 5) | 334 ± 77 | 80 ± 33 | 12 ± 2 | 319 ± 109 | 660 ± 254 |
| Stomach | 184 ± 59 | 7 ± 1 | — | 4 ± 1 | 21 ± 3 |
| Testis (n = 19) | 14 ± 2 | 2.0 ± 0.3 | 1.0 ± 0.3 | 13 ± 3 | 6 ± 1 |
| Thyroid (n = 65) | 11 ± 1 | 3 ± 1 | — | 1.0 ± 0.1 | — |
| Trachea | 693 ± 76 | 26 ± 9 | 7.0 ± 0.5 | 32 ± 7 | 27 ± 8 |
| Uterus (n = 10) | 53 ± 13 | — | — | — | — |
—, not detected.