TABLE 2

Mean inhibitor concentrations evaluated for metabolic drug-drug interaction prediction

Inhibitor	Victim	Victim Route	Inhibitor Plasma or Blood Concentration
Inhibitor	Victim	Victim Route	C_avg,u	C_max,obs,u	[I]_in,u (C_avg)^a	[I]_in,u (C_max)^a
			μM
Fluvoxamine	Caffeine	p.o.	0.231	0.375	6.71	6.85
Ketoconazole	Midazolam	p.o.	0.362	1.41	1.24	2.29
Ketoconazole	Midazolam	i.v.	0.883	1.98	1.77	2.86
Ketoconazole	Temazepam	p.o.	0.505	1.39	1.39	2.28
Fluoxetine	Bufuralol	p.o.	0.589	0.885	1.52	1.81
Clomipramine	Bufuralol	p.o.	0.016	0.033	0.167	0.184

↵a Estimates of hepatic vein inlet concentration ([I]_in) were corrected with published human B:P partitioning values when possible (see Table 3).