fu | |||
---|---|---|---|
Beagle Plasma | Bloodb | Control Bactosomesc | |
Fluvoxamine | 0.132 ± 0.033 | 0.240 | 0.249 ± 0.017 |
Ketoconazole | 0.017 ± 0.010 | 0.025 | 0.345 ± 0.044 |
Fluoxetine | 0.019 ± 0.002 | 0.035 | 0.156 ± 0.015 |
Clomipramine | 0.005 ± 0.003 | 0.005 | 0.157 ± 0.002 |
↵a Values represent the mean ± S.D.
↵b Calculated from published human B:P partition ratios for fluvoxamine and fluoxetine (McGinnity et al., 2008), ketoconazole (Shibata et al., 2008), and beagle plasma binding.
↵c Protein and drug concentrations were chosen to mimic the conditions of Ki experiments.