Dose, duration of bile collection, and observed biliary excretion of 25 literature compounds in BDC rats
The mean of the differences is 3.9%, and the mean of the absolute differences is 13% of dose.
| Compound | Dose | Bile Collection | Observation | Reference |
|---|---|---|---|---|
| mg/kg | h | % dose | ||
| BMS-182874 | 48 | 12 | 0.9 | Chong et al., 2003 |
| BMS-187345 | 45 | 12 | 4.5 | Chong et al., 2003 |
| BMS-387032 | 8.9 | 9 | 11.0 | Kamath et al., 2005a |
| Cephradine | 25 | 6 | 27.3 | Moriwaki et al., 2003 |
| Dasatinib | 10 | 9 | 9.6 | Kamath et al., 2008 |
| Digitoxin | 0.01 | 4 | 53.7 | Funakoshi et al., 2003 |
| Digoxin | 0.08 | 12 | 59.0 | Russell and Klaassen, 1973 |
| DNP-NAC | 0.05 | 1 | 42.0 | Hinchman et al., 1998 |
| EPE-glucuronide | 1 | 24 | 64.5 | Payan et al., 1999 |
| Erythromycin | <1 | 1 | 34.0 | Akashi et al., 2006 |
| Estradiol-17β-glucuronide | <1 | 1 | 87.0 | Akashi et al., 2006 |
| Fexofenadine | 11.8 | 9 | 69.8 | Kamath et al., 2005b |
| Irinotecan (lactone form) | 10 | 4 | 7.0 | Arimori et al., 2003 |
| Irinotecan (carboxylate form) | 10 | 4 | 59.8 | Arimori et al., 2003 |
| Lissamine fast yellow | 25.25 | 3 | 90.0 | Hirom et al., 1972b |
| Methotrexate | 10 | 2.5 | 72.0 | Masuda et al., 1997 |
| 7-Hydroxymethotrexate | 4.0 | 3.3 | 72.0 | Fahrig et al., 1989 |
| Olmesartan | <1 | 3 | 83.0 | Takayanagi et al., 2005 |
| Ouabain | 0.08 | 12 | 55.0 | Russell and Klaassen, 1973 |
| Paclitaxel | 10 | 24 | 11.5 | Monsarrat et al., 1990 |
| Phenolphthalein glucuronide | 24.8 | 3 | 82.0 | Hirom et al., 1972b |
| Pravastatin (carboxylate form) | <1 | 1 | 80.0 | Kurihara et al., 2005 |
| Sitagliptin | 2.0 | 72 | 16.4 | Beconi et al., 2007 |
| Vinblastine | <1 | 1.5 | 30.0 | Kurihara et al., 2005 |
| Vincristine | 0.5 | 2 | 42.6 | Song et al., 1999 |
BMS-187345, 5-methylamino-N-(3,4-dimethyl-5-isoxaxolyl)-1-naphthalene sulfonamide; BMS-387032, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4 piperidinecarboxamide; DNP-NAC, S-2,4-dinitrophenyl-N-acetylcystein; EPE, 1-(2′-ethylphenyl)ethanol.