Relative abundance of biliary and fecal metabolites of anacetrapib in rat and monkey after oral administration of 10 mg/kg [14C]anacetrapib
| Analytes | Percentage of Radioactivity Dosea | |||
|---|---|---|---|---|
| Rat | Monkey | |||
| Bile | Feces | Bile | Feces | |
| Anacetrapib | 0.7 | 63 | N.D. | 74 |
| M1 | 0.2 | 4.8 | N.D. | 2.8 |
| M2 | N.D. | 2.7 | N.D. | 2.7 |
| M3 | 0.7 | 5.6 | 0.1 | 5.0 |
| M4 | 1.7 | N.D. | 1.1 | N.D. |
| M5 | 3.5 | N.D. | 0.9 | N.D. |
| M6 | 0.5 | N.D. | 0.5 | N.D. |
| M7 | 3.3 | N.D. | 0.5 | N.D. |
| M8 | 0.5 | N.D. | 0.7 | N.D. |
| M9 | 0.5 | N.D. | N.D. | N.D. |
| M10 | 0.2 | N.D. | N.D. | N.D. |
| M11 | N.D. | N.D. | 0.4 | N.D. |
| M12 | N.D. | N.D. | 2.8 | N.D. |
| M13 | N.D. | N.D. | 0.7 | N.D. |
N.D., not detected.
↵a Calculation was based on dose recovery during the first 48-h period. Approximately 1 to 2% of the dose was detected in urine, and the radioactivity in urine was too low for meaningful analysis.