Pharmacokinetic parameters of PR-104 metabolites in mouse and human plasma after intravenous administration of 975 mg/m2 (bolus) and 1100 mg/m2 (60-min infusion), respectively
| Mouse | Human* | |||
|---|---|---|---|---|
| AUC0-inf | t1/2 | AUC0-inf | t1/2 | |
| μmol-h/l | min | μmol-h/l | min | |
| PR-104 | 80.7 | 3.4 | 19.0 (1.6) | 7.1 (1.0) |
| PR-104A | 81.6 | 16.8 | 34.9 (4.2) | 39.7 (1.4) |
| PR-104H (M22) | 3.0 | 23.9 | 1.75 (0.2) | 41.5 (3.3) |
| PR-104M (M23) | 10.2 | 20.5 | 0.29 (0.04) | 60.6 (5.5) |
| PR-104S1 (M8) | 19.3 | 24.7 | 0.78 (0.17) | 53.0 (4.5) |
| PR-104G (M1) | 2.7 | 13.1 | 44.6 (16.2) | 35.3 (2.1) |
↵* The PK for PR-104 and PR-104A are in good agreement with the values reported elsewhere (Jameson et al., 2009), for 6 of the same 10 subjects, using a different analytical method.