TABLE 4

Plasma concentrations of total radioactivity, vabicaserin, and CG (ng equivalents/ml) in mice, rats, and dogs after a single oral administration of [¹⁴C]vabicaserin^{^a}

Time	Mouse			Rat			Dog
Time	Total	Vabicaserin	CG	Total	Vabicaserin	CG	Total	Vabicaserin	CG
h	50 mg/kg, n = 4–5			5 mg/kg, n = 3			15 mg/kg, n = 2–3
Male
2	3819 ± 622	582 ± 173	582 ± 199	632 ± 144	87 ± 35	N.D.	422 ± 573	31	120
4	3771 ± 512	475 ± 177	773 ± 293	659 ± 17	91 ± 23	N.D.	564 ± 748	199	108
8	3263 ± 624	385 ± 135	491 ± 116	465 ± 43	59 ± 16	N.D.	528 ± 566	5 ± 8	13 ± 22
24	597 ± 213	24 ± 16	213 ± 119	47 ± 8	N.A.	N.A.	1340 ± 508	28 ± 24	107 ± 135
AUC_0–24^b	56,357	6631	10,097	8267	1037	N.D.	18,536	933	1550
Female
2	5250 ± 583	999 ± 181	344 ± 157	658 ± 189	132 ± 61	N.D.	N.A.	N.A.	N.A.
8	2868 ± 615	356 ± 135	375 ± 183	338 ± 61	49 ± 13	N.D.	N.A.	N.A.	N.A.

N.D., not detected; N.A., data not available.
↵a Data are presented as mean ± S.D. or the average of two subjects.
↵b AUC_0–24 values were calculated with mean plasma concentrations using WinNonlin 5.1 (Pharsight) and were presented as ng-Eq · h/ml.