Two-compartment pharmacokinetic parameter estimates after a single 5 mg/kg i.v. or s.c. dose of anti-TNF-α mAb WT, N434A, and N434H to SCID mice
| Parameter | Parameter Estimates (CV%) | ||
|---|---|---|---|
| WT | N434A | N434H | |
| ka (1/day) | 1.34 (22.9) | 0.930 (21.5) | 1.11 (27.1) |
| Vc (ml/kg) | 37.9 (2.51) | 37.2 (2.02) | 56.3 (2.04) |
| CL (ml/day/kg) | 5.07 (8.68) | 5.92 (9.34) | 16.1 (9.41) |
| F (%) | 73.2 (8.59) | 72.4 (9.24) | 61.3 (12.5) |
| t1/2,β (day) | 11.6 | 11.9 | 6.60 |
CV, coefficient of variation of the estimate.