TABLE 3

Noncompartmental pharmacokinetic parameter estimates after a single 5 mg/kg i.v. dose of anti-TNF-α mAb WT, N434A, or N434H to cynomolgus monkeys

Data are means ± S.D. There is no significant different between the N434A group and N434H group for AUCdays 0–7 and C0.

PK ParameterWild TypeN434AN434H
AUCdays 0–7 (μg/ml · day)592 ± 56.8749 ± 71.9* (1.27a)819 ± 81.5* (1.38a)
C0 (μg/ml)144 ± 14.3178 ± 25.8212 ± 26.5*

  • ↵* P < 0.05 compared with the wild type.

  • ↵a Fold compared with the wild type.