Plasma mean pharmacokinetic parameters of semagacestat and total radioactivity in healthy male human subjects after a single 140-mg (100 μCi) oral dose of [14C]semagacestat dihydrate
| Geometric Mean (CV%) (n = 6) | ||
|---|---|---|
| Semagacestat | Total Radioactivity (Radioequivalents) | |
| Cmax (ng/ml) | 2160 (19) | 3050 (19) |
| Tmaxa (h) | 0.51 (0.50–1.00) | 0.51 (0.50–1.00) |
| t1/2b (h) | 2.35 (2.11–2.58) | 14.3 (13.0–16.4) |
| AUC0-tlast (ng · h/ml) | 6590 (7) | 22600 (15) |
| AUC0-∞ (ng · h/ml) | 6600 (7) | 23100 (15) |
| AUC0–24 (ng · h/ml) | 6590 (7) | 18300 (14) |
| CL/F (l/h) | 21.2 (7) | 6.07 (15) |
AUC0-tlast, area under the concentration versus time curve from time 0 to time t where t is the last time point with a measurable concentration; AUC0-∞, area under the concentration versus time curve from zero to infinity; AUC0–24, area under the concentration time curve from 0- to 24-h time point; CV%, coefficient of variation.
↵a Median (range).
↵b Geometric mean (range).