P450 | Liver Biopsies | Subcutaneous WAT | Visceral WAT | |||
---|---|---|---|---|---|---|
Explants (t = 0) | Explants (t = 48 h) | Adipocytes | Explants (t = 0) | Explants (t = 48 h) | ||
CYP1A1 | 24,432 | 571 ± 1080 | 8561 ± 6494 | 71 ± 59 | 222 ± 220 | 1839 ± 1258 |
CYP1A2 | 323,914 | N.D. | N.D. | 4 ± 2 | N.D. | N.D. |
CYP1B1 | 1884 | 1251 ± 564 | 8396 ± 3793 | 71,850 ± 14,605 | 9336 ± 2119 | 18,461 ± 5081 |
CYP2A6 | 144,272 | N.D. | N.D. | N.D. | 14 ± 19 | N.D. |
CYP2A7 | 28,956 | N.D. | N.D. | N.D. | N.D. | N.D. |
CYP2B6 | 49,353 | 50 ± 54 | 192 ± 304 | 19 ± 8 | 76 ± 42 | 19 ± 8 |
CYP2C18 | 54,865 | 219 ± 121 | N.D. | N.D. | 104 ± 98 | 9 ± 3 |
CYP2C19 | 74,445 | 60 ± 50 | N.D. | N.D. | 48 ± 40 | 7 ± 3 |
CYP2C8 | 360,803 | 41 ± 31 | 116 ± 139 | 23 ± 13 | 246 ± 286 | 46 ± 20 |
CYP2C9 | 494,491 | 9 ± 18 | N.D. | N.D. | 40 ± 36 | N.D. |
CYP2D6 | 86,014 | 145 ± 22 | 139 ± 64 | 120 ± 49 | 337 ± 99 | 166 ± 46 |
CYP2E1 | 3,244,323 | 155 ± 40 | 98 ± 25 | 105 ± 52 | 268 ± 202 | 136 ± 24 |
CYP2J2 | 50,999 | 17 ± 24 | 7 ± 5 | 5 ± 1 | 349 ± 304 | 78 ± 77 |
CYP2R1 | 457 | 133 ± 90 | 510 ± 186 | 265 ± 71 | 239 ± 83 | 505 ± 161 |
CYP2S1 | 895 | 201 ± 153 | 97 ± 54 | 7 ± 4 | 247 ± 95 | 148 ± 78 |
CYP2U1 | 2610 | 2135 ± 803 | 1750 ± 846 | 3599 ± 345 | 3567 ± 1041 | 1890 ± 539 |
CYP3A4 | 50,5805 | 116 ± 83 | 6 ± 6 | N.D. | 30 ± 11 | 2 ± 1 |
CYP3A43 | 5094 | 18 ± 14 | N.D. | 4 ± 1 | 14 ± 81 | 12 ± 1 |
CYP3A5 | 75,422 | 426 ± 358 | 199 ± 77 | 6 ± 4 | 350 ± 45 | 89 ± 36 |
CYP3A7 | 16,355 | N.D. | N.D. | N.D. | 30 ± 18 | 3 ± 7 |
N.D., not detected (Ct >33).