TABLE 1

Percent recovery of the dose in healthy male volunteers, Sprague-Dawley rats, and Beagle dogs after intravenous administration of [¹⁴C]zoniporide

[¹⁴C]Zoniporide was administered intravenously to humans at a dose of 80 mg and to Sprague-Dawley rats and Beagle dogs at a dose of 10 and 3 mg/kg, respectively.

Time	% of Dose
Time	Urine	Feces	Total
Healthy male volunteers
0–24 h	33	2.3	35.3
0–48 h	34	33	67
0–72 h	34	56	90
0–96 h	34	56	90
0–120 h	34	56	90
0–144 h	34	57	91
Rats
0–24 h	27	57	84
0–48 h	28	59	86
0–72 h	28	60	88
0–96 h	28	60	88
0–120 h	28	60	88
0–144 h	28	61	89
0–168 h	28	61	89
Dogs
0–24 h	25	47	71
0–48 h	26	58	84
0–72 h	26	60	86
0–96 h	27	61	88
0–120 h	27	61	88
0–144 h	27	61	88
0–168 h	27	62	89