TABLE 3

Percentage of urinary and fecal metabolites of zoniporide after intravenous administration of [14C]zoniporide to healthy male volunteers, Sprague-Dawley rats, and Beagle dogs

Healthy male volunteers were administered [14C]zoniporide by intravenous infusion for 1 h at a dose of 80 mg (100 μCi). The rats were administered a bolus of [14C]zoniporide at a dose of 10 mg/kg (50 μCi). The dogs were administered a bolus of [14C]zoniporide at a dose of 3 mg/kg (150 μCi).

Metabolites% Dose Excreted
Healthy Male VolunteersSprague-Dawley RatsBeagle Dog
UrineFecesTotalUrineFecesTotalUrineFecesTotal
M1163652102535
M21717
M30.80.80.77.98.6
M42.12.1
M50.761.32.11.24.15.4
M61.41.4
M75.95.94.14.1
M81.71113
M92.12.1
M100.291818
Zoniporide171.018122840181937