TABLE 5 Estimation of exposure of metabolites M1 and M3 in rat plasma
Metabolite/parent ratio was determined from the abundance of the metabolite (% total circulating radioactivity) and parent (% total circulating radioactivity) in the plasma. Estimated exposure of metabolite = (metabolite/parent ratio)·AUCzoniporide. The AUC of zoniporide was determined after quantitation of the parent by a bioanalytical assay.