Mean concentrations of radioactivity in tissues and gastrointestinal contents after a single oral (5 mg/kg) administration of [1′-14C]stavudine to male rats
| Matrix | Concentrationa | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | |
| 1 h | 4 h | 12 h | 24 h | 48 h | 96 h | 168 h | ||||||||
| Adrenal glands | 1.53 | 0.52 | 0.75 | 1.12 | 0.06 | 0.01 | 0.04 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 |
| Blood | 1.64 | 0.11 | 0.10 | 0.04 | 0.05 | 0.00 | 0.03 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 |
| Bone (femur) | 0.41 | 0.06 | 0.07 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Bone marrow (femur) | 1.75 | 0.08 | 0.15 | 0.07 | 0.05 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Brain | 0.28 | 0.01 | 0.09 | 0.02 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Cecum | 1.03 | 0.09 | 0.61 | 0.22 | 0.12 | 0.05 | 0.03 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Cecum contents | 0.06 | 0.03 | 0.49 | 0.14 | 0.05 | 0.04 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Eyes | 1.10 | 0.12 | 0.13 | 0.03 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 |
| Heart | 1.16 | 0.07 | 0.05 | 0.02 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Intestinal contents, large | 0.01 | 0.01 | 0.11 | 0.09 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Intestinal contents, small | 1.11 | 0.29 | 0.06 | 0.05 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Intestine, large | 1.52 | 0.08 | 0.65 | 0.11 | 0.16 | 0.09 | 0.03 | 0.02 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 |
| Intestine, small | 8.40 | 0.22 | 1.12 | 1.22 | 0.08 | 0.00 | 0.03 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Kidneys | 6.14 | 1.17 | 0.51 | 0.31 | 0.06 | 0.00 | 0.03 | 0.01 | 0.03 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 |
| Liver | 2.19 | 0.40 | 0.53 | 0.15 | 0.24 | 0.01 | 0.14 | 0.02 | 0.11 | 0.01 | 0.05 | 0.00 | 0.03 | 0.00 |
| Lungs | 1.57 | 0.12 | 0.10 | 0.03 | 0.03 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 |
| Plasma | 1.77 | 0.13 | 0.09 | 0.04 | 0.03 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Skeletal muscle (pectoral) | 1.50 | 0.21 | 0.05 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Skeletal muscle (thigh) | 1.44 | 0.28 | 0.07 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Skin, nonpigmented | 1.30 | 0.19 | 0.10 | 0.05 | 0.04 | 0.01 | 0.02 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 |
| Skin, pigmented | 1.34 | 0.25 | 0.09 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Spleen | 1.24 | 0.13 | 0.30 | 0.39 | 0.04 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 |
| Stomach | 5.54 | 1.51 | 0.20 | 0.11 | 0.04 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Stomach contents | 1.06 | 0.09 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Testes | 1.05 | 0.11 | 0.26 | 0.05 | 0.03 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 |
| Thyroid | 1.90 | 0.72 | 0.20 | 0.12 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Urinary bladder | 78.10 | 52.80 | 13.50 | 16.50 | 0.03 | 0.00 | 0.03 | 0.02 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 |
↵a μg-Eq of stavudine/g.